Software tool for 3D extraction of germinal centers
نویسندگان
چکیده
منابع مشابه
Textbook germinal centers?
Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of their principal assumptions into question. In addition, the term germ...
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Germinal centers (GCs)—the sites of antibody development—are not exclusive niches for rookie B cells. They are also open to experienced old-timers, according to Bende et al. (page 2655). GCs are temporary lymph node structures that form during an immune response to help newly activated B cells better recognize an antigen. As they proliferate, the B cells’ antibody-encoding DNA is mutated. The e...
متن کاملGerminal centers: A second childhood for lymphocytes
Recent observations show that, in the peripheral lymphoid organs known as germinal centers, lymphocytes appear to regain the phenotypic and molecular traits of immature cells; this cellular regression may play an important role in the affinity maturation of immune responses.
متن کاملGerminal Centers without T Cells
Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode their receptors for antigen. This process can change Ab affinity and specificity. The mutated cells t...
متن کاملClonal Evolution of Autoreactive Germinal Centers.
Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies. This response is a central driver of pathogenesis in autoimmune diseases, such as systemic lupus erythematosus (SLE), but the natural history of autoreactive GCs remains unclear. Here, we present a novel mouse model where the presence of a single...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2013
ISSN: 1471-2105
DOI: 10.1186/1471-2105-14-s6-s5